On your Appframe Web installation there should be a menu with various developer commands such as new app, edit app, article list, edit sidebar and edit site. These commands are typically located on the profile dropdown in the sidebar.
To get a basic app up and running all you have to do is to add and configure a data source (remember to add columns) and write markup that references that data source.
A powerful tool, espescially if you are new to Appframe Web 2016 is the Code Builder. This is a tool that based on the specific data sources for your app can generate usable markup.
Database Manager allows you to test, inspect, create and modify: tables, views, triggers and stored procedures. You can also simply run queries. Database Manager is only available on Pims365-based Appframe installations.
Site setup is where global settings for your whole site are set up. For most appframe installations the changes you need to make here should be minimal. Changing the sidebar or mega menu is not done here. That is done with a edit sidebar or edit mega menu commannd.
Use Alt + 1 to toggle sourcelist.